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Aseptic meningitis caused by sandfly fever virus, serotype Toscana
T F Schwarz1, S Gilch, G Jäger
1Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany.
Abstract:
Sandfly fever virus, serotype Toscana (TOS), is endemic in some Mediterranean countries and causes sandfly fever (pappataci fever). In some patients, TOS may cause meningitis and meningoencephalitis. We report on two German adults returning from Italy with TOS-related meningitis, complicated in one case by abducens nerve palsy. TOS infection should be considered as a cause of acute central nervous system disorders in patients returning from areas of endemicity.
Insights
Sandfly fever virus Toscana (TOS) can cause meningitis and meningoencephalitis. Consider TOS infection in patients with neurological symptoms returning from endemic areas.
Area of Science:
- Virology
- Neurology
- Infectious Diseases
Background:
- Sandfly fever virus serotype Toscana (TOS) is endemic in Mediterranean regions.
- TOS causes sandfly fever (pappataci fever) and can lead to neurological complications like meningitis and meningoencephalitis.
Observation:
- Two German adults returning from Italy presented with TOS-related meningitis.
- One patient experienced a complication of abducens nerve palsy.
Findings:
- Confirmed TOS infection as the cause of meningitis in both patients.
- Documented TOS-induced central nervous system disorders, including cranial nerve palsy.
Implications:
- Highlights the importance of considering TOS infection in differential diagnoses for acute CNS disorders.
- Emphasizes the need for awareness among clinicians regarding TOS as a potential neuroinvasive pathogen in travelers returning from endemic areas.