Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bulbospinal catecholamine neurones and sympathetic pattern generation

J H Coote1, D I Lewis

  • 1Department of Physiology, Medical School, University of Birmingham, UK.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Life-long learning in laboratory animal science and ethics for veterinary and para-veterinary professionals in South Africa.

Journal of the South African Veterinary Association·2023
Same author

Learning outcomes for the education and training of laboratory animal caretakers in South Africa.

Journal of the South African Veterinary Association·2023
Same author

Palliative Lung Radiotherapy: Higher Dose Leads to Improved Survival?

Clinical oncology (Royal College of Radiologists (Great Britain))·2020
Same author

Special issue, 'Central and peripheral nerve influence on cardiac function in health and disease'.

Autonomic neuroscience : basic & clinical·2016
Same author

The sympathetic innervation of the heart: Important new insights.

Autonomic neuroscience : basic & clinical·2016
Same author

Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats.

Acta physiologica (Oxford, England)·2015
Same journal

Danggui Shaoyao San alleviates nephrotic syndrome by regulating inerleukin 13/signal transducer and activator of transcription 6 axis.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2026
Same journal

Effect of short-term of vaginal therapy with prasterone before urogynecological surgery in woman.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2026
Same journal

Parthenolide ameliorates metabolic dysfunction-associated steatohepatitis by inhibiting M1 polarization by suppressing the nuclear factor-κB pathway.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2026
Same journal

Glutamyl-tRNA synthetase 2 regulates mitochondrial biogenesis and reactive oxygen species homeostasis mediatingenzalutamide resistance by targeting striatin 4 in prostate cancer cells.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2026
Same journal

Regulation of the KEAP1/NRF2 pathway by claudin-2-targeted lymphoid enhancer-binding factor 1 binding in gastric cancer progression.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2026
Same journal

Mulberry leaf supplementation improves glycemic control but not renal or cardiovascular markers in spontaneously hypertensive rats.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2026
See all related articles

Catecholamines modulate sympathetic preganglionic neurones (SPN) in the spinal cord, influencing cardiovascular regulation. These neurotransmitters can excite or inhibit SPN via various adrenoceptors and ionic conductances.

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Neuropharmacology

Background:

  • Noradrenaline, dopamine, and adrenaline neurons project to the spinal cord, innervating sympathetic preganglionic neurons (SPN).
  • Catecholamines play a role in regulating the cardiovascular system through their actions on SPN.

Purpose of the Study:

  • To investigate the mechanisms by which catecholamines influence SPN activity.
  • To elucidate the role of different adrenoceptors and ionic conductances in mediating catecholamine effects on SPN.
  • To understand how catecholamine actions on SPN contribute to cardiovascular regulation.

Main Methods:

  • Experiments were conducted on rats.
  • Intrathecal drug application to the spinal cord was used.
  • Iontophoresis and drug superfusion techniques were employed.

Related Experiment Videos

  • Extracellular and intracellular recordings of SPN activity and postganglionic nerve activity were performed.

    • Main Results:

    • Catecholamines were found to either excite or inhibit SPN.
    • Alpha 1 adrenoceptors mediated slow depolarization, while alpha 2 adrenoceptors mediated slow hyperpolarization.
    • Catecholamines can excite glycinergic interneurons, leading to fast inhibitory postsynaptic potentials (IPSPs) in SPN.
    • Regulation of ionic conductances by catecholamines induces tonic discharge or bursting oscillations in SPN.
    • Excitatory amino acids can modify these catecholamine-induced actions.

    Conclusions:

    • Catecholamines exert complex modulatory effects on SPN, influencing their firing patterns.
    • These actions, mediated by specific adrenoceptors and ionic mechanisms, allow for differential regulation of sympathetic outflow.
    • The findings suggest a significant role for catecholaminergic pathways in controlling cardiovascular function via spinal sympathetic circuits.