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Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating
A W Roberts1, E DeLuca, C G Begley
1Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Stem Cells (Dayton, Ohio)
|September 1, 1995
Summary
Granulocyte colony-stimulating factor (G-CSF) mobilizes myeloid progenitor cells. Previous chemotherapy/radiotherapy significantly reduces progenitor cell levels in cancer patients, highlighting the need for careful consideration in stem cell transplantation strategies.
Area of Science:
- Hematology
- Oncology
- Stem Cell Biology
Background:
- Granulocyte colony-stimulating factor (G-CSF) is used to increase white cell counts (WCC) and mobilize myeloid progenitor cells.
- Understanding variations in progenitor cell mobilization is crucial for therapeutic applications, particularly in cancer patients.
Purpose of the Study:
- To investigate the impact of G-CSF on white cell counts and myeloid progenitor cell levels.
- To assess inter-individual variations in progenitor cell mobilization in response to G-CSF.
- To determine the effect of prior chemo/radiotherapy on G-CSF-induced progenitor cell mobilization.
Main Methods:
- Studied G-CSF treatment effects in three groups: previously treated cancer patients, untreated cancer patients, and normal volunteers.
- Measured absolute levels of circulating progenitor cells and total white cells.
- Analyzed variations in progenitor cell numbers and WCC across different patient groups.
Main Results:
- Pretreated cancer patients showed significantly lower absolute circulating progenitor cell levels compared to untreated cancer patients.
- Wide inter-individual variations in progenitor cell numbers were observed in all groups, exceeding variations in WCC.
- Normal volunteers exhibited considerable variance in progenitor cell levels, comparable to pretreated cancer patients.
Conclusions:
- Previous chemo/radiotherapy significantly impairs G-CSF-induced myeloid progenitor cell mobilization in cancer patients.
- Broad physiological variations in G-CSF-induced progenitor cell levels necessitate careful consideration for allogeneic peripheral blood stem cell transplantation protocols.