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Published on: November 10, 2008
Changes in a CSF antigen associated with dementia
M T Carretero1, C R Harrington, C M Wischik
1Cambridge Brain Bank Laboratory, University of Cambridge Department of Psychiatry, UK.
Abstract:
An 85-kDa antigen was detected in cerebrospinal fluid (CSF) using a monoclonal antibody, 11.57, raised against a fraction of paired helical filaments extracted from Alzheimer's disease (AD) brain tissues. The antigen is a thermostable protein that is unrelated either to tau or amyloid beta-protein precursor. Its level was measured in lumbar and post-mortem CSF samples and found to be decreased significantly in patients with dementia as compared with non-demented controls. There was no difference in its level between patients with AD and those with non-Alzheimer type dementia. In AD, however, there was a significant relationship between disease progression and the amount of the 85-kDa antigen.
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