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Computation of heart surface potentials using the surface source model

H D Simms1, D B Geselowitz

  • 1Bioengineering Program, Pennsylvania State University, University Park, USA.

Journal of Cardiovascular Electrophysiology
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

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A novel heart surface source model simplifies cardiac electrophysiology calculations. This model effectively relates cellular action potentials to heart surface potentials, aiding in understanding cardiac electrical activity.

Area of Science:

  • Cardiac Electrophysiology
  • Biophysics
  • Computational Biology

Background:

  • The bidomain model relates cardiac current source density to transmembrane action potential gradients.
  • Under specific conditions, cardiac sources can be represented by a double layer on the heart surface.
  • This heart surface source model simplifies potential calculations from cardiac sources.

Purpose of the Study:

  • To develop and validate a heart surface source model for calculating epicardial potentials.
  • To investigate the impact of insulating the heart surface on simulated electrograms.

Main Methods:

  • Utilized the heart surface source model to compute epicardial potentials.
  • Simulated electrograms for normal, ischemic, and infarcted heart conditions.

Related Experiment Videos

  • Assessed the effect of heart surface insulation on simulated electrograms.

    • Main Results:

    • The model successfully calculated epicardial potentials for various cardiac conditions.
    • Insulating the heart surface significantly increased simulated electrogram amplitude (nearly fourfold) with minimal waveshape alteration.
    • Simulated electrograms demonstrated good correlation with literature-reported experimental data.

    Conclusions:

    • The heart surface source model provides a viable framework for linking heart surface potentials to cellular action potential distributions.
    • This model offers a simplified yet effective approach to cardiac electrophysiology modeling.