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Hemostatic activity of organs in declamping shock
S Głowiński1, M Gacko, J Głowiński
1Department of Vascular Surgery and Transplantology, Medical Academy of Bialystok.
Roczniki Akademii Medycznej W Bialymstoku (1995)
|January 1, 1995
Summary
Declamping shock affects blood clotting factors in organs. While most clotting activities remained stable, kidneys and lungs showed increased antiplasmin activity, potentially increasing thrombotic risks.
Area of Science:
- Physiology
- Pathophysiology
- Biochemistry
Background:
- Declamping shock, a condition arising after aortic cross-clamping, can lead to significant physiological disturbances.
- Understanding the impact on hemostatic components is crucial for managing potential complications.
Purpose of the Study:
- To investigate the activity of key hemostatic components within various organs during declamping shock.
- To identify organ-specific alterations in coagulation and fibrinolysis.
Main Methods:
- Surgical induction of declamping shock by cross-clamping the abdominal aorta.
- Assay of tromboplastic, antithrombin, plasminogen activator, and antiplasmin activities in kidney, liver, lung, heart, and skeletal muscle tissues.
- Comparative analysis of activity levels between control and shock states.
Main Results:
- No significant changes in tromboplastic and antithrombin activities were observed in the kidney, liver, lung, heart, and skeletal muscle.
- Elevated plasminogen activator activity was noted in the renal cortex, medulla, and lungs.
- Considerably higher antiplasmin activity was detected in the renal cortex, medulla, and lungs.
Conclusions:
- Declamping shock induces specific alterations in fibrinolytic components within the kidney and lung.
- Increased antiplasmin activity in these organs may contribute to a prothrombotic state.
- Further research is warranted to explore the clinical implications of these findings on thrombotic complication risk.