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Related Experiment Videos

Small bowel permeability--a variable effect of NSAIDS

V M Choi1, J E Coates, J Chooi

  • 1Department of Medicine, University of Alberta, Edmonton.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|October 1, 1995
PubMed
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Non-steroidal anti-inflammatory drugs (NSAIDs) like indomethacin and sustained-release diclofenac significantly increase small bowel permeability. Other NSAIDs, including conventional diclofenac and tenoxicam, showed no significant effect on gut permeability.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Toxicology

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used but can cause gastrointestinal side effects.
  • Assessing the impact of different NSAIDs and their formulations on small bowel permeability is crucial for understanding their safety profiles.

Purpose of the Study:

  • To evaluate the effects of various NSAIDs, including diclofenac sodium, diclofenac SR, indomethacin, and tenoxicam, on small bowel permeability in healthy volunteers.

Main Methods:

  • Small bowel permeability was assessed using the dual-sugar absorption method (mannitol and 51Cr-EDTA recovery in urine).
  • Healthy volunteers ingested NSAID medications for one week before undergoing permeability studies.

Main Results:

Related Experiment Videos

  • Indomethacin and sustained-release (SR) diclofenac significantly increased small bowel permeability.
  • Conventional-release diclofenac showed a trend towards increased permeability, but not statistically significant.
  • Tenoxicam (Mobiflex) did not significantly alter small bowel permeability.

Conclusions:

  • Different NSAIDs and different formulations of the same NSAID can have varying effects on small bowel permeability.
  • Sustained-release diclofenac appears to have a more pronounced effect on small bowel permeability compared to conventional diclofenac sodium.