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Transient incidental glucosuria in children

J Rajantie, J Mäkelä, J Mäenpää

European Journal of Pediatrics

|October 1, 1995

Summary

Transient asymptomatic glucosuria in children can predict insulin-dependent diabetes mellitus. Early detection of islet cell antibodies and impaired insulin response may guide preventative therapies.

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Area of Science:

Pediatrics
Endocrinology
Metabolic Disorders

Background:

Transient asymptomatic glucosuria is a condition observed in children.
The long-term implications and predictive value of this finding require further investigation.

Purpose of the Study:

To investigate the long-term outcomes of children diagnosed with transient asymptomatic glucosuria.
To identify risk factors associated with the development of insulin-dependent diabetes mellitus in this cohort.

Main Methods:

A cohort of 78 children with transient asymptomatic glucosuria was prospectively followed for up to 7.3 years.
Patients were assessed for blood glucose levels, islet cell antibodies, and first-phase insulin response.

Main Results:

Five patients (6.4%) developed insulin-dependent diabetes mellitus within 2.1 years.
These patients exhibited higher blood glucose levels and, in three cases, positive islet cell antibodies with subnormal first-phase insulin response.
Among the remaining children, islet cell antibodies were found in 3, and 12/55 had impaired first-phase insulin response, with some showing deterioration and others normalization.

Conclusions:

Transient glucosuria in children, especially when accompanied by islet cell antibodies and a subnormal first-phase insulin response, indicates a risk for developing insulin-dependent diabetes mellitus.
Consideration of therapeutic interventions in high-risk children is warranted to prevent overt diabetes.

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