Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paracentric inversions: a review

K Madan1

  • 1Cytogenetics Laboratory, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.

Human Genetics
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Most paracentric inversions in humans are harmless, with a low risk of unbalanced karyotypes in offspring. However, distinguishing them from insertions is crucial due to higher associated risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing laparoscopic and robotic splenectomy: A systematic review of the outcomes.

Journal of minimal access surgery·2025
Same author

Indian National Association for the Study of the Liver Position Statements on Prevention, Diagnosis, and Management of Hepatitis B Virus Infection in India.

Journal of clinical and experimental hepatology·2025
Same author

Fibroblastic reticular cell tumor of eyelid: Rare case report and review of literature.

Indian journal of pathology & microbiology·2024
Same author

Short-term exposure to air pollution and emergency room visits for acute respiratory symptoms among adults.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
Same author

Prolonged Itraconazole Therapy as Sole Treatment for Patients with Allergic Fungal Rhinosinusitis.

The Laryngoscope·2023
Same author

Clues from the Pandora's Box: Frequency of Acute Abdominal Symptoms in COVID-19 and Its Association with Inflammatory Markers-a Cross-Sectional Study.

The Indian journal of surgery·2022
Same journal

AI in variant analysis: fast track to genetic diagnoses.

Human genetics·2026
Same journal

Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder.

Human genetics·2026
Same journal

Investigating the shared genetic architecture between selective immunoglobulin A deficiency and autoimmune diseases.

Human genetics·2026
Same journal

ARHI as a key regulator of EMT and metastasis in pancreatic cancer via the Notch-1 pathway.

Human genetics·2026
Same journal

Large-scale mitogenome analysis reveals complex maternal genetic connections between Sino-Tibetan- and Altaic-speaking populations.

Human genetics·2026
Same journal

Correction: A comprehensive and accessible model for co-segregation analysis in BRCA1, BRCA2, and PALB2 variant classification.

Human genetics·2026
See all related articles

Area of Science:

  • Human genetics
  • Cytogenetics
  • Reproductive biology

Background:

  • Paracentric inversions are chromosomal rearrangements.
  • Their reproductive consequences are studied across species.
  • Understanding these inversions is vital for genetic counseling.

Purpose of the Study:

  • To review the behavior and reproductive outcomes of paracentric inversions in humans.
  • To assess the risks associated with paracentric inversions.
  • To provide guidance on interpreting prenatal diagnoses.

Main Methods:

  • Review of 184 cases of paracentric inversions in humans.
  • Inclusion of data from naturally occurring inversions in plants and animals.
  • Consideration of experimental results from mutagenically induced inversions in mice.

Related Experiment Videos

Main Results:

  • The majority of human paracentric inversions appear to be harmless.
  • The risk for heterozygotes to have a child with an unbalanced karyotype is generally low.
  • Distinguishing inversions from insertions is challenging and carries different risk levels (approx. 15% for insertions).

Conclusions:

  • Most paracentric inversions in humans pose minimal reproductive risk.
  • Careful interpretation of prenatal diagnostic results is necessary due to potential for unpredictable unbalanced chromosome products.
  • Accurate differentiation between paracentric inversions and insertions is critical for risk assessment.