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Related Experiment Videos

Elastomeric valves, a new design

M H Hulsbergen1, S Topaz, A Kumar

  • 1Kolff's Laboratory, University of Utah, Salt Lake City, USA.

The International Journal of Artificial Organs
|April 1, 1995
PubMed
Summary
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The new convex bileaflet valve offers easier manufacturing and high cardiac output. Testing indicates good flow and minimal thrombosis, suggesting a promising future for this cardiac valve replacement.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Prosthetic Valve Technology

Background:

  • Traditional flat biflap inflow and tricuspid semilunar outflow valves present manufacturing challenges.
  • Development of novel prosthetic valves is crucial for improving cardiac device performance.
  • Convex bileaflet valves are being explored as an alternative to existing designs.

Purpose of the Study:

  • To evaluate the performance and characteristics of a newly developed convex bileaflet valve.
  • To compare the convex bileaflet valve against existing valve designs in terms of manufacturing and function.
  • To assess the hemodynamic performance and thrombogenicity of the convex bileaflet valve across various ventricle sizes.

Main Methods:

  • Convex bileaflet valves were developed for 11, 20, 40, 70, and 140cc ventricles.

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  • Performance was assessed using mock circulation loops for hemodynamic testing (Cardiac Output vs. Venous Pressure, Cardiac Output vs. Heart Rate).
  • Flow visualization, paint studies, and bloodbag studies were conducted to evaluate flow dynamics and thrombogenicity.

    • Main Results:

    • Hemodynamic testing demonstrated high cardiac output, even at heart rates exceeding 150 BPM.
    • Flow visualization revealed optimal flow through the sinus of Valsalva with no stagnant regions.
    • Bloodbag studies showed minimal thrombosis, primarily on valve edges, which was preventable with heparinization.

    Conclusions:

    • The convex bileaflet valve demonstrates superior hemodynamic performance and favorable flow characteristics.
    • Manufacturing ease and reduced thrombogenicity suggest significant advantages over current valve designs.
    • The convex bileaflet valve shows considerable potential for future applications in cardiac replacement therapy.