Migraine with aura as the presentation of leukemia

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Updated: Nov 6, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

E B Geller1, P Y Wen

  • 1Division of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Headache
|October 1, 1995
PubMed

Insights

New-onset migraine with aura can be an early indicator of acute promyelocytic leukemia and disseminated intravascular coagulation. This rare association highlights potential links between platelet serotonin and migraine development.

Area of Science:

  • Neurology
  • Hematology
  • Oncology

Background:

  • Migraine with aura is a complex neurological condition.
  • Acute promyelocytic leukemia (APML) is a subtype of leukemia.
  • Disseminated intravascular coagulation (DIC) is a condition of abnormal blood clotting.

Observation:

  • A case study of a male patient presenting with new-onset migraine with aura.
  • The patient was subsequently diagnosed with acute promyelocytic leukemia and disseminated intravascular coagulation.

Findings:

  • This presentation represents a previously unreported association between migraine with aura and APML/DIC.
  • The findings suggest a potential role for platelet serotonin in the pathogenesis of migraine.

Implications:

  • Further research should investigate the prevalence of migrainous symptoms in APML and DIC patients.
  • Increased awareness may improve diagnosis and patient reporting, especially in critically ill individuals.

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