Related Experiment Videos
Migraine with aura as the presentation of leukemia
1Division of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Abstract:
We present the case of a man with new onset of migraine with aura as the presenting sign of acute promyelocytic leukemia and disseminated intravascular coagulation. This previously unreported association may support theories of platelet serotonin involvement in the pathogenesis of migraine. It would be valuable in the future to evaluate other patients with disseminated intravascular coagulation or acute promyelocytic leukemia for the presence of migrainous auras or headaches, symptoms which may be underreported by patients, particularly in the setting of severe illness.
Insights
New-onset migraine with aura can be an early indicator of acute promyelocytic leukemia and disseminated intravascular coagulation. This rare association highlights potential links between platelet serotonin and migraine development.
Area of Science:
- Neurology
- Hematology
- Oncology
Background:
- Migraine with aura is a complex neurological condition.
- Acute promyelocytic leukemia (APML) is a subtype of leukemia.
- Disseminated intravascular coagulation (DIC) is a condition of abnormal blood clotting.
Observation:
- A case study of a male patient presenting with new-onset migraine with aura.
- The patient was subsequently diagnosed with acute promyelocytic leukemia and disseminated intravascular coagulation.
Findings:
- This presentation represents a previously unreported association between migraine with aura and APML/DIC.
- The findings suggest a potential role for platelet serotonin in the pathogenesis of migraine.
Implications:
- Further research should investigate the prevalence of migrainous symptoms in APML and DIC patients.
- Increased awareness may improve diagnosis and patient reporting, especially in critically ill individuals.