Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Association between mannan binding protein deficiency and recurrent miscarriage

D C Kilpatrick1, B H Bevan, W A Liston

  • 1University Department of Anatomy, Edinburgh, UK.

Human Reproduction (Oxford, England)
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can ficolin-2 (L-ficolin) insufficiency be established by a single serum protein measurement?

International journal of immunogenetics·2015
Same author

Drug modification of LPS-stimulated human monocyte-derived dendritic cells.

British journal of biomedical science·2012
Same author

Mechanisms and assessment of mitogenesis : an overview.

Methods in molecular medicine·2011
Same author

Use of lectins as mitogens for lymphocytes.

Methods in molecular medicine·2011
Same author

Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term.

BJOG : an international journal of obstetrics and gynaecology·2008
Same author

MBL really binds to healthy human cells!

Scandinavian journal of immunology·2007

Low mannan binding protein (MBP) levels in partners of couples with recurrent miscarriage suggest increased susceptibility to fetal loss. This may be linked to infection-induced placental issues.

Area of Science:

  • Immunology
  • Reproductive Medicine
  • Genetics

Background:

  • Mannan-binding protein (MBP) is a key component of the innate immune system.
  • Recurrent miscarriage affects a significant number of couples, with underlying causes often remaining unclear.

Purpose of the Study:

  • To determine normal concentrations of MBP in blood donor sera.
  • To investigate the association between MBP levels and recurrent miscarriage in couples.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify MBP concentrations.
  • Immunohistochemistry was employed to detect MBP in placental tissue.

Main Results:

  • Abnormally low MBP concentrations were observed in 16% of female and 14% of male partners of couples with recurrent miscarriage, compared to <5% in controls.

Related Experiment Videos

  • The association was more pronounced in individuals homozygous for the MBP deficiency allele.
  • MBP was detected in first-trimester placenta tissue.

    • Conclusions:

    • Low MBP concentrations in the feto-placental unit may increase susceptibility to fetal loss.
    • Infection-induced placental cytokine imbalance is a potential mechanism contributing to recurrent miscarriage in MBP-deficient individuals.