Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective peripheral denervation for spasmodic torticollis: is the outcome predictable?

V Braun1, H P Richter, J M Schröder

  • 1Department of Neurosurgery, University of Ulm, Günzburg, Germany.

Journal of Neurology
|August 1, 1995
PubMed
Summary

For cervical dystonia patients unresponsive to botulinum toxin, selective peripheral denervation offers surgical benefits. Prior positive response to botulinum toxin predicts surgical success, while nerve histology does not significantly impact outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pioneers in Dermatology and Venereology: an interview with Professor Jens-Michael Schröder.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Pustular diseases and keratinocyte-myeloid synergy.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Novel SBF2 mutations and clinical spectrum of Charcot-Marie-Tooth neuropathy type 4B2.

Clinical genetics·2018
Same author

Right ventricular stroke volume variation: a tool to assess right ventricular volume responsiveness.

Minerva anestesiologica·2013
Same author

Novel TPM3 mutation in a family with cap myopathy and review of the literature.

Neuromuscular disorders : NMD·2013
Same author

[Development of epidural spinal cord stimulation. Fortieth anniversary of the first implantation in Germany].

Schmerz (Berlin, Germany)·2013

Area of Science:

  • Neurology
  • Neurosurgery
  • Medical Science

Background:

  • Cervical dystonia is a debilitating neurological movement disorder.
  • Botulinum toxin is a primary treatment, but efficacy is limited in some patients.
  • Selective peripheral denervation is the preferred surgical option when botulinum toxin fails.

Purpose of the Study:

  • To evaluate predictors of success for selective peripheral denervation in cervical dystonia.
  • To investigate the role of prior botulinum toxin response and nerve histology in surgical outcomes.

Main Methods:

  • Retrospective analysis of patients undergoing selective peripheral denervation for cervical dystonia.
  • Correlation of surgical outcomes with pre-operative botulinum toxin response.
  • Analysis of histological findings of resected peripheral nerves.

Related Experiment Videos

Main Results:

  • A positive response to previous botulinum toxin therapy significantly predicted better outcomes after selective peripheral denervation (P < 0.01).
  • Histological examination of resected nerves did not reveal a significant difference in outcomes between patients with pathological versus normal nerves (P < 0.30).

Conclusions:

  • Pre-treatment botulinum toxin response is a strong predictor of success in selective peripheral denervation for cervical dystonia.
  • Nerve histology is not a significant factor in determining the success of this surgical procedure.