Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelin subtypes: effect on isolated rhesus monkey ciliary muscle

C Millar1, J F Poyer, B T Gabelt

  • 1Department of Ophthalmology and Visual Sciences, Medical School, University of Wisconsin-Madison, USA.

The Journal of Pharmacology and Experimental Therapeutics
|December 1, 1995
PubMed
Summary

Endothelin-1 (ET-1) weakly contracts rhesus monkey ciliary muscle, primarily via the ETA receptor. Its longitudinal vector sensitivity suggests a role in trabecular meshwork deformation, impacting intraocular pressure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uterine health and reproductive hormones in genetically divergent Holstein-Friesian and Jersey cows evaluated under seasonal pasture-based management systems.

Journal of dairy science·2025
Same author

Attenuated psychosis symptoms are related to working alliance between therapist and service user.

Early intervention in psychiatry·2024
Same author

Evaluation of delayed timing of artificial insemination with sex-sorted sperm on pregnancy per artificial insemination in seasonal-calving, pasture-based lactating dairy cows.

Journal of dairy science·2020
Same author

Long term effects of gestational hypertension and pre-eclampsia on kidney function: Record linkage study.

Pregnancy hypertension·2016
Same author

PP038. Are women with gestational hypertension or preeclampsia at an increased long term risk of kidney function impairment?

Pregnancy hypertension·2015
Same author

Why and how do we classify von Willebrand disease?

Haemophilia : the official journal of the World Federation of Hemophilia·2015

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Physiology

Background:

  • Endothelin (ET) compounds are potent vasoconstrictors.
  • The ciliary muscle plays a crucial role in regulating intraocular pressure and accommodation.
  • The specific effects of ET-1 on ciliary muscle contractility are not fully understood.

Purpose of the Study:

  • To investigate the contractile effects of endothelin-1 (ET-1), ET-2, ET-3, and sarafotoxin S6C on isolated rhesus monkey ciliary muscle.
  • To determine the receptor subtype involved in ET-1's action on the ciliary muscle.
  • To explore the potential mechanisms by which ET-1 influences ocular dynamics.

Main Methods:

  • Isolated ciliary muscle strips from young and middle-aged rhesus monkeys were used.
  • Contractile force was measured simultaneously in longitudinal and coronal vectors.

Related Experiment Videos

  • Responses to ET compounds were compared to carbachol, a known ciliary muscle agonist.

    • Main Results:

    • ET-1 induced weak contractions (up to 15% of carbachol response) in 66% of muscle strips.
    • The longitudinal vector was approximately 5-fold more sensitive to ET-1 than the circular vector.
    • Only ET-1 showed contractile effects, suggesting ETA receptor predominance.

    Conclusions:

    • ET-1 elicits weak, variable contractions in rhesus monkey ciliary muscle, primarily through ETA receptors.
    • ET-1's enhancement of outflow facility may involve direct effects on the trabecular meshwork.
    • Selective longitudinal ciliary muscle contraction by ET-1 could deform the trabecular meshwork, influencing intraocular pressure.