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Serum cortisol levels in children with dengue haemorrhagic fever

Myo-Khin1, Soe-Thein, Thein-Thein-Myint

  • 1Department of Medical Research, Yangon, Union of Myanmar.

Journal of Tropical Pediatrics
|October 1, 1995
PubMed

Insights

This study found that children with Dengue Haemorrhagic Fever (DHF) in Myanmar did not experience cortisol insufficiency. Serum cortisol levels were elevated during acute illness, particularly in cases with shock.

Area of Science:

  • Pediatric Infectious Diseases
  • Endocrinology
  • Tropical Medicine

Background:

  • Dengue Haemorrhagic Fever (DHF) poses a significant pediatric health risk in Myanmar.
  • Cortisol sufficiency is crucial during severe infections.

Purpose of the Study:

  • To investigate cortisol levels in children with dengue infection.
  • To determine if cortisol insufficiency occurs in Dengue Haemorrhagic Fever.

Main Methods:

  • Serum cortisol levels were measured in 62 children with dengue infection (DHF and dengue fever).
  • A control group of 26 children with non-dengue viral infections was included.
  • Cortisol levels were assessed during acute and convalescent illness stages.

Main Results:

  • Children with DHF exhibited significantly higher serum cortisol levels compared to controls (P < 0.05).
  • Highest mean cortisol levels were observed in DHF cases with shock.
  • Acute stage cortisol levels in DHF were double those in the convalescent stage.

Conclusions:

  • No evidence of cortisol insufficiency was found in children with Dengue Haemorrhagic Fever.
  • Elevated cortisol levels during acute DHF suggest a potential stress response rather than deficiency.

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