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Related Experiment Videos

Erythrocyturia, smoking, and occupation

S C Freni, L M Dalderup, J J Oudegeest

    Journal of Clinical Pathology
    |April 1, 1977
    PubMed
    Summary
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    Microscopic hematuria (erythrocytes in urine) is common in older men and strongly linked to smoking. This finding may indicate a risk for urinary bladder cancer due to smoking-induced metabolites.

    Area of Science:

    • Urology
    • Oncology
    • Toxicology

    Background:

    • Microscopic hematuria, defined as erythrocytes in urine, is a potential indicator of urinary tract abnormalities.
    • Smoking is a known risk factor for various cancers, including urinary bladder cancer.
    • Tryptophan metabolism can be altered by smoking, potentially leading to carcinogenic metabolite production.

    Purpose of the Study:

    • To investigate the prevalence of microscopic hematuria in healthy older men.
    • To explore potential correlations between hematuria and factors like tobacco consumption and occupation.
    • To assess the significance of smoking-induced metabolites in relation to microhematuria and bladder cancer risk.

    Main Methods:

    • Analysis of urine samples from 432 healthy men aged 50 and over.

    Related Experiment Videos

  • Quantification of erythrocytes per high-power field in urine.
  • Statistical correlation analysis with tobacco consumption and occupational data.

    • Main Results:

    • 19.2% of participants had one or more erythrocytes per high-power field; 8.1% had over 10.
    • Erythrocyturia showed a strong correlation with tobacco consumption.
    • No significant association was found with occupation, though data were limited.

    Conclusions:

    • Microscopic hematuria is prevalent in healthy older men and significantly associated with smoking.
    • Smoking may induce abnormal tryptophan metabolism, producing carcinogenic orthoaminophenols.
    • Microhematuria could serve as a valuable early sign of urinary bladder cancer in smokers.