[Neuro-psychiatric involvement in primary Sjögren's syndrome]

Area of Science:

• Neurology
• Immunology
• Psychiatry

Context:

• Primary Sjögren's syndrome (PSJS) is a systemic autoimmune disease with diverse organ involvement.
• Neuro-psychiatric manifestations are increasingly recognized in PSJS patients.
• The extent and nature of central nervous system (CNS) involvement remain debated.

Purpose:

• To summarize the current literature on neuro-psychiatric involvement in primary Sjögren's syndrome.
• To highlight the prevalence and types of neurological and psychiatric symptoms in PSJS.
• To address the controversy surrounding CNS involvement, including multiple sclerosis-like symptoms.

Summary:

• Neuro-psychiatric complications are significant in primary Sjögren's syndrome (PSJS).
• Peripheral nervous system (PNS) and central nervous system (CNS) disorders are increasingly reported.
• Depression, anxiety, and trigeminal neuropathy are common, affecting up to 10% of patients.

Impact:

• This review synthesizes existing knowledge on neuro-psychiatric aspects of PSJS.
• It underscores the need for further research into the underlying mechanisms.
• Improved understanding can lead to better diagnosis and management of PSJS-related neuro-psychiatric conditions.