Thyroid therapy in HIV-infected patients

Ten HIV-positive patients were given thyroid hormone in pharmacological doses. Two patients that had CD4 counts of 200 or higher responded well with gain in weight, energy, endurance and well-being within 6 months. During the same period, their CD4 counts rose to within normal limits and remained there. One patient has been well for 3 years and the other for 1 year. Six other patients with counts below 200 have had variable clinical improvements during the first 6 months but no change in CD4 counts. Thyroid therapy in pharmacological doses helps most patients with symptoms of fatigue or depression. At the same time, it may retard or prevent the progression from HIV infection to AIDS.