Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leukocyte adhesion molecules as a cofactor in AIDS: basic science and pilot study

A D Allen1, D N Hart, M K Hechinger

  • 1CytoDyn of New Mexico, Inc., Santa Fe 87501, USA.

Medical Hypotheses
|August 1, 1995
PubMed
Summary

A human immunologic cofactor (HIC), potentially leukocyte adhesion molecules, may cause AIDS alongside HIV infection. Targeting LFA-1 adhesion epitopes with antibody fragments reduced HIV viral load in a pilot study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala.

Molecular psychiatry·2014
Same author

Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety.

Molecular psychiatry·2014
Same author

Radical additions of TEMPO to ketenes: correlation of free radical and nucleophilic reactivity.

Organic letters·2005
Same author

Dendritic cells and their emerging clinical applications.

Pathology·2002
Same author

Generation, observation, and free radical reactivity of aliphatic bisketenes: the solution to a long-standing problem.

Organic letters·2001
Same author

Antiaromaticity in open-shell cyclopropenyl to cycloheptatrienyl cations, anions, free radicals, and radical ions.

Chemical reviews·2001

Area of Science:

  • Immunology
  • Virology
  • Cell Biology

Background:

  • The Acquired Immunodeficiency Syndrome (AIDS) pandemic is linked to Human Immunodeficiency Virus (HIV) infection.
  • Koch's postulates are not fully satisfied for AIDS, suggesting a potential human immunologic cofactor (HIC) involved.
  • Leukocyte adhesion molecules are hypothesized as a potential HIC due to microbiological findings.

Purpose of the Study:

  • To investigate the role of leukocyte adhesion molecules as a potential HIC in AIDS.
  • To evaluate the therapeutic effect of targeting LFA-1 adhesion epitopes in patients with HIV disease.

Main Methods:

  • A pilot study involving patients with HIV disease.
  • Infusion of a monoclonal mouse antibody (MmAb) against an LFA-1 adhesion epitope.

Related Experiment Videos

  • Administration of F(ab) and F(ab)2' fragments binding to the same epitope but non-immunogenic.

    • Main Results:

    • Both MmAb and antibody fragments significantly reduced peripheral viral burden in HIV patients.
    • The non-immunogenic fragments were more effective in reducing viral burden than the MmAb.
    • MmAb treatment increased circulating CD4+ T lymphocytes and resolved cutaneous anergy, likely due to mitogenic properties.

    Conclusions:

    • Leukocyte adhesion molecules, specifically LFA-1, may function as a human immunologic cofactor in AIDS pathogenesis.
    • Targeting LFA-1 with antibody fragments shows potential for reducing viral load in HIV disease.
    • Further research is warranted to elucidate the role of HICs and LFA-1 in AIDS and explore therapeutic strategies.