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[Primary gastric lymphoma. 14 clinical cases]
P Pradella1, L Maculotti, G Sesana
1Divisione di Chirurgia Generale Andrea Ponti, Ospedale Ca Granda Niguarda, Milano.
Minerva Chirurgica
|July 1, 1995
Summary
Surgical and adjuvant chemotherapy for primary gastric lymphoma showed promising results, with a median survival of 32 months for treated patients. Survival rates varied by grade and stage, indicating histology and staging negatively influenced outcomes.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Oncology
Context:
- Primary gastric lymphoma is a rare malignancy.
- Treatment strategies involve surgery and chemotherapy.
- Retrospective analysis of patient outcomes is crucial for treatment optimization.
Purpose:
- To evaluate the efficacy of surgical and adjuvant chemotherapy in primary gastric lymphoma.
- To analyze survival rates based on histological grade and clinical stage.
Summary:
- Fourteen patients with primary gastric lymphoma underwent retrospective analysis.
- 79% received surgery (subtotal/total gastrectomy) and 64% adjuvant chemotherapy (CHOP/CVP).
- High-grade malignancy was most common (57%), with stage IIE1 prevalent (43%). Median survival was 21 months overall, 32 months for treated patients. 5-year survival was 10% overall, 14% treated, 50% low-grade, 33% stage IE.
Impact:
- Surgical and chemotherapeutic interventions significantly improved median survival.
- Histology and staging were identified as negative prognostic factors.
- Findings contribute to understanding treatment effectiveness in gastric lymphoma.