Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatocarcinogenesis in transgenic mice

E P Sandgren1, G Merlino

  • 1Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706, USA.

Progress in Clinical and Biological Research
|January 1, 1995
PubMed
Summary

Transgenic mouse models offer new ways to study liver growth and disease. Researchers can now test gene functions in vivo and explore liver regeneration for potential human liver development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insomnia and daytime sleepiness predict 20-year mortality in older male adults: data from a population-based study.

Sleep medicine·2020
Same author

miR-30e* is an independent subtype-specific prognostic marker in breast cancer.

British journal of cancer·2015
Same author

Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study.

Sleep medicine·2010
Same author

Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.

Oncogene·2010
Same author

Melanoma from bench to bedside: meeting report from the 6th international melanoma congress.

Pigment cell & melanoma research·2009
Same author

A 38 kg skin-reducing bilateral mastectomy: a unique case.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2008

Area of Science:

  • Hepatology
  • Molecular Biology
  • Transgenic Animal Models

Background:

  • Altered hepatic gene expression is key to understanding liver growth.
  • Transgenic mouse models provide tools to study liver development and disease.
  • Liver's regenerative capacity offers novel research avenues.

Purpose of the Study:

  • To investigate the molecular mechanisms of normal and pathological liver growth.
  • To test the transforming potency of known carcinogenic genomic changes in the liver.
  • To measure the in vivo contribution of genetic changes to liver growth.

Main Methods:

  • Utilizing transgenic mouse models with altered hepatic gene expression.
  • Employing liver injury models to study regenerative capacity.
  • Combining transgenic technology with embryonic stem cell techniques for gene manipulation.

Main Results:

  • Demonstrated the ability to test carcinogenic genomic changes in vivo.
  • Showcased liver regeneration potential, with donor cells reconstituting up to 80% of recipient liver.
  • Enabled direct measurement of genetic contributions to liver growth.

Conclusions:

  • Transgenic mouse models are powerful tools for liver research.
  • Liver regeneration and gene manipulation technologies open new possibilities for studying liver growth.
  • These advancements facilitate answering critical questions about liver growth regulation in intact animals.

Related Experiment Videos