Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does tumor control decrease by prolonging overall treatment time or interrupting treatment in laryngeal cancer?

W Van den Bogaert1, A Van der Leest, A Rijnders

  • 1Department of Radiotherapy, University Hospital Leuven, Belgium.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First branchial cleft anomalies in children: long-term outcome in 16 patients.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2025
Same author

Suicidal sodium nitrite intoxication: a case report focusing on the postmortem findings and toxicological analyses-review of the literature.

Forensic science, medicine, and pathology·2023
Same author

Salvage Transoral Laser Microsurgery for Radiorecurrent Laryngeal Cancer: Indications, Limits, and Outcomes.

Current otorhinolaryngology reports·2017
Same author

TRACHEAL ALLOTRANSPLANTATION AND REGENERATION.

Acta chirurgiae plasticae·2016
Same author

Microbial Community Dynamics and Response to Plant Growth-Promoting Microorganisms in the Rhizosphere of Four Common Food Crops Cultivated in Hydroponics.

Microbial ecology·2016
Same author

Abstracts from the 8th Annual Meeting of the Scientific Association of Swiss Radiation Oncology (SASRO).

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016
Same journal

Definitive IMRT alone with reduced prophylactic nodal irradiation for Early-Stage Oropharyngeal Cancer: JCOG1208.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Associations between body composition and radiotherapy-related side-effects and health-related quality of life in patients with prostate or lung cancer: sub-analysis of the REQUITE trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

ESTRO recommendations for the use, planning and delivery of reirradiation in locally recurrent rectal cancer - Endorsed by ASTRO.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Early ADC changes in risk-model-defined brain regions precede contrast-enhancing lesions after proton therapy for low-grade glioma.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Any impact of pre-operative radiotherapy on renal function in retroperitoneal soft tissue sarcomas? A secondary ancillary analysis of the EORTC 62092 STRASS 1 trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Tumor volume reduction during adaptive radiotherapy is a strong prognostic factor for oropharyngeal cancer: A retrospective multicenter study?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
See all related articles

Radiotherapy interruptions negatively impact local control rates in laryngeal cancer, particularly in glottic tumors. Prolonged overall treatment time, a stronger factor, significantly affects outcomes, especially in T2 glottic cancer.

Area of Science:

  • Oncology
  • Radiotherapy
  • Laryngeal Cancer Research

Background:

  • Radiotherapy is a primary treatment for laryngeal cancer.
  • Treatment interruptions and overall treatment time are critical factors influencing radiotherapy outcomes.
  • Understanding these factors is crucial for optimizing laryngeal cancer treatment protocols.

Purpose of the Study:

  • To evaluate radiotherapy treatment results in laryngeal cancer.
  • To investigate the impact of treatment interruptions on local control rates.
  • To analyze the influence of overall treatment time on local control using multivariate analysis.

Main Methods:

  • Retrospective analysis of 864 patients treated with primary radiotherapy between 1962 and 1986.
  • Comparison of split-course (2-week interruption after 50 Gy) versus continuous treatment.

Related Experiment Videos

  • Actuarial calculation of local control rates and multivariate analysis to identify independent prognostic factors.

    • Main Results:

    • Univariate analysis revealed significantly lower local control rates in glottic cancer with split-course radiotherapy.
    • Multivariate analysis identified site, total dose, total treatment time, T stage, and N stage as significant factors influencing local control.
    • Overall treatment time was a significant negative predictor of local control, especially in T2 glottic cancer.

    Conclusions:

    • Treatment interruption negatively influences local control in glottic laryngeal cancer.
    • Prolonged overall treatment time significantly reduces local control rates in laryngeal cancer patients.
    • Optimizing radiotherapy schedules to minimize treatment time is essential for improving outcomes in laryngeal cancer, particularly for specific tumor subgroups.