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Can phenytoin lower plasma fibrinogen concentrations?
C Goerdt1, H B Rubins, W Swaim
1Section of General Internal Medicine, School of Public Health, University of Minnesota, USA.
Thrombosis Research
|August 1, 1995
Summary
This study investigated if phenytoin reduces plasma fibrinogen levels, a marker linked to cardiovascular disease. While phenytoin showed a trend toward lower fibrinogen, results were not statistically significant.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Clinical Trials
Background:
- Elevated plasma fibrinogen is a significant risk factor for cardiovascular disease.
- Understanding factors that modulate fibrinogen levels is crucial for cardiovascular risk management.
Purpose of the Study:
- To evaluate the efficacy of phenytoin in reducing plasma fibrinogen concentrations.
- To assess the dose-dependent effect of phenytoin on fibrinogen levels in a clinical trial setting.
Main Methods:
- A randomized, placebo-controlled, double-blind trial was conducted.
- Participants received varying daily doses of phenytoin (100 mg, 200 mg, 300 mg) or placebo for 14 weeks.
- Plasma fibrinogen levels were measured pre- and post-treatment in a subset of subjects.
Main Results:
- Phenytoin-treated subjects showed a mean reduction of 0.24 g/l (8%) in fibrinogen levels compared to placebo.
- This reduction did not reach statistical significance (p = 0.3).
- A trend towards lower fibrinogen levels was observed with phenytoin treatment.
Conclusions:
- Phenytoin may have the potential to reduce plasma fibrinogen levels.
- Further research with larger sample sizes is warranted to confirm these findings and explore clinical significance.