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Updated: Aug 11, 2026

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
Published on: April 3, 2011
Lymphoblastoid cell lines are polyclonal activators of human T lymphocytes
Abstract:
Following stimulation with autologous or allogeneic lymphoblastoid cell lines (LCL) human T lymphocytes acquire two properties which suggest that LCL act as polyclonal activators. Cytotoxic activity, which has an antigen-specific component, is produced towards normal lymphocytes and LCL, and the cells become capable of mounting proliferative responses to antigens on human B lymphocytes which have accelerated secondary-type kinetics. Only weak responses to autologous cells occur. In addition, repeated restimulation with the original LCL leads to a progressive increase in the number of cells in the culture for a period of about 4 weeks. This approach may prove a useful way to grow large numbers of human T lymphocytes for further study.
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