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[Peripheral autonomic nervous system function in patients with hypothalamic insufficiency]
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|January 1, 1995
Summary
Subclinical peripheral nervous system insufficiency is common in hypothalamic insufficiency, particularly in early or long-term cases. This may contribute to autonomic dysfunction like tachycardia and panic attacks.
Area of Science:
- Neuroendocrinology
- Autonomic Nervous System Research
- Clinical Neurology
Background:
- Hypothalamic insufficiency can lead to complex neuroendocrine and autonomic dysfunctions.
- Understanding the peripheral nervous system's role is crucial for managing these patients.
Purpose of the Study:
- To assess the peripheral vegetative nervous system state in patients with constitutional acquired hypothalamic insufficiency.
- To identify correlations between autonomic dysfunction and disease characteristics or dysraphic status.
Main Methods:
- Non-invasive cardiovascular tests were employed to evaluate autonomic function.
- Electrophysiological assessment of sudomotor preganglionic fiber conductivity was performed.
- Patients with hypothalamic insufficiency were compared to a healthy control group.
Main Results:
- Subclinical parasympathetic vegetative insufficiency was detected, more pronounced in early-onset or long-standing hypothalamic insufficiency.
- Reduced conductivity velocity in sudomotor preganglionic fibers of the limbs was observed.
- Autonomic dysfunction was more prevalent in patients with significant dysraphic status, suggesting potential developmental defects.
Conclusions:
- The findings support a constitutional and acquired nature of autonomic disturbances in hypothalamic insufficiency.
- Subclinical peripheral autonomic insufficiency may be a key factor in developing permanent or paroxysmal autonomic symptoms.
- Dysraphic status may indicate underlying defects in peripheral vegetative fiber development.