[Peripheral autonomic nervous system function in patients with hypothalamic insufficiency]

Peripheral vegetative nervous system state was estimated in 61 patients with constitutional acquired hypothalamic insufficiency by using non-invasive methods. Control group consisted of 10 healthy individuals. Cardiovascular tests application led to the evaluation of subclinical parasympathetic vegetative insufficiency. In was more prominent in patients with early neuroendocrine disorders debut as well as in those with more protracted disease durations. The authors suggest that these findings testify the constitutional acquired character of disturbances. Besides it was also found the conductivity velocity fall in sudomotor preganglionic fibers in arms and legs and the prevalence of such disorders in patients with expressed dysraphic status. The last observation may testify the defect in laying of these peripheral vegetative fibers. The study carried out permits to suppose that subclinical peripheral insufficiency occur to be one of the factors evoking rise either of permanent (tachycardia, arterial pressure elevation, hyperhidrosis) or of paroxysmal vegetative disturbances (panic attacks, migraine) in patients with hypothalamic insufficiency.