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[The modification of Bacillus intermedius ribonuclease by urea derivatives]
Abstract:
The results of the "Bacillus intermedius" RNAase modification by urea derivatives are presented. The modifiers synthesized for that purpose were the following: N-(4-chlorbenzoyl)-N'-benzolsulfonyl urea (M1) and N-(4-chlorbenzoyl)carbomoyl-epsilon-aminocapronic acid (M2). It was shown that RNAase modified by M2 stimulated the cell general metabolism by the test of the cell absorption of neutral red and had a more marked ability to disrupt RNA of the cell plasmatic membranes in comparison to that of the native enzyme.
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