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Reversible ophthalmoplegia in CPEO

I S Dunlop¹, P Dunlop

¹Sydney Eye Hospital, Woolloomooloo, NSW.

Australian and New Zealand Journal of Ophthalmology

|August 1, 1995

Summary

Coenzyme Q10 supplementation improved ocular motility in a patient with chronic progressive external ophthalmoplegia (CPEO). This finding suggests CoQ10 may help limit ophthalmoplegia progression.

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Area of Science:

Neurology
Ophthalmology
Biochemistry

Background:

Chronic progressive external ophthalmoplegia (CPEO) is a debilitating neuromuscular disorder affecting eye movements.
Mitochondrial dysfunction is implicated in the pathogenesis of CPEO.
Coenzyme Q10 (CoQ10) is a vital component of the mitochondrial electron transport chain.

Observation:

A single patient diagnosed with CPEO was treated with Coenzyme Q10.
The treatment involved daily supplementation of 300 mg CoQ10 for three years.
A brief trial of 200 mg daily was conducted after one year.

Findings:

Significant improvement in ocular motility was observed during CoQ10 treatment.
Ocular ductions, measured by synoptophore, demonstrated enhancement.
The positive effects on eye movements were sustained throughout the treatment period.

Implications:

Coenzyme Q10 may be a beneficial therapeutic agent for managing CPEO.
This case highlights the potential role of CoQ10 in mitigating mitochondrial-related ophthalmoplegia.
Further research into CoQ10's efficacy in larger CPEO cohorts is warranted.

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