Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Doxacurium block is not influenced by age

J C De Mey1, G Rolly, N Den Blauwen

  • 1Department of Anesthesiology, University Hospital, Ghent, Belgium.

Journal of Clinical Anesthesia
|September 1, 1995
PubMed
Summary

Elderly patients can safely receive doxacurium, a neuromuscular blocker, without dose adjustments. This finding supports its use in older individuals undergoing surgery, including those with cardiac conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mechanisms of carbon monoxide production by inhalational agents.

Anaesthesia·2006
Same author

Time course of inhaled anaesthetic drug delivery using a new multifunctional closed-circuit anaesthesia ventilator. In vitro comparison with a classical anaesthesia machine.

British journal of anaesthesia·2004
Same author

Production of compound A and carbon monoxide in circle systems: an in vitro comparison of two carbon dioxide absorbents.

Anaesthesia·2004
Same author

Postoperative residual curarization with cisatracurium and rocuronium infusions.

European journal of anaesthesiology·2002
Same author

A paravenous approach for the saphenous nerve block.

Regional anesthesia and pain medicine·2001
Same author

Only carbon dioxide absorbents free of both NaOH and KOH do not generate compound A during in vitro closed-system sevoflurane: evaluation of five absorbents.

Anesthesiology·2001

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Geriatric Medicine

Background:

  • Aging influences drug pharmacokinetics and pharmacodynamics.
  • Doxacurium is a neuromuscular blocking agent used in anesthesia.
  • The safety and efficacy of doxacurium in elderly populations require specific investigation.

Purpose of the Study:

  • To evaluate the impact of aging on the efficacy and safety of doxacurium.
  • To determine if doxacurium requires dose adjustments in elderly patients.

Main Methods:

  • An open-label, randomized, phase III study was conducted.
  • 30 elderly patients (≥65 years) were compared to 30 younger adult patients (18-64 years).
  • Neuromuscular function was monitored electromyographically during elective ophthalmic surgeries exceeding 2 hours under general anesthesia.

Main Results:

  • No significant differences were observed in the maximum neuromuscular block achieved or onset time between elderly and younger groups.
  • The clinical duration of the neuromuscular block was comparable in both age groups.
  • Hemodynamic changes associated with doxacurium administration were clinically insignificant.

Conclusions:

  • Doxacurium can be safely administered to elderly patients without the need for dose modification.
  • Doxacurium presents a potentially suitable option for patients with cardiac disease undergoing prolonged surgical procedures.
  • The study supports the use of doxacurium across different age groups in anesthesia.

Related Experiment Videos