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Related Experiment Videos

Nicardipine: applications in anesthesia practice

J D Tobias1

  • 1Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.

Journal of Clinical Anesthesia
|September 1, 1995
PubMed
Summary

Nicardipine, an intravenous dihydropyridine calcium channel blocker, effectively controls perioperative blood pressure. It offers vasodilatation with minimal impact on heart function, proving safe for various surgical patients.

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Area of Science:

  • Anesthesiology
  • Cardiovascular Pharmacology

Background:

  • Nicardipine is the first intravenously administered dihydropyridine calcium channel blocker.
  • It primarily causes vasodilatation with limited effects on myocardial inotropic and dromotropic function.

Purpose of the Study:

  • To review the pharmacology and physiology of nicardipine.
  • To discuss its applications in clinical anesthesia and interactions with anesthetic drugs.

Main Methods:

  • Review of existing literature on nicardipine's use in anesthesia.
  • Analysis of its physiological effects and clinical applications.

Main Results:

  • Nicardipine effectively controls intraoperative and postoperative blood pressure.
  • It has been utilized in major vascular and cardiovascular surgeries and for controlled hypotension.
  • Preliminary data indicate safe and effective perioperative blood pressure management.

Conclusions:

  • Nicardipine is a safe and effective agent for managing perioperative blood pressure.
  • Its vasodilatory properties make it valuable in anesthesia, particularly in cardiovascular surgery.

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