Immunoglobulin allotypes and RFLPs in disease association

¹Department of Applied Biology and Biotechnology, Royal Melbourne Institute of Technology, Vic., Australia.

Experimental and Clinical Immunogenetics

|January 1, 1995

Abstract:

Immunoglobulin heavy chain (Gm) and light chain (Km) allotypes have been extensively studied as possible markers of susceptibility to a range of immune-related diseases including malignancies, infectious diseases and autoimmune disorders. This review is concentrated on susceptibility to multiple sclerosis, systemic lupus erythematosus and insulin-dependent diabetes mellitus.

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