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Fuchs' heterochromic uveitis and sarcoidosis
1Academic Unit of Ophthalmology, Birmingham and Midland Eye Hospital.
The British Journal of Ophthalmology
|November 1, 1995
Summary
Fuchs heterochromic uveitis (FHU) may be a secondary ocular response to sarcoidosis, not a primary condition. Investigations for sarcoidosis are recommended for patients diagnosed with FHU.
Area of Science:
- Ophthalmology
- Immunology
- Pulmonology
Background:
- The etiology of Fuchs heterochromic uveitis (FHU) is unknown.
- FHU can be associated with various ocular conditions.
- This study investigated five patients with FHU and sarcoidosis.
Observation:
- Five patients with FHU and sarcoidosis were studied.
- Four patients had elevated serum angiotensin converting enzyme (sACE) levels.
- One patient had a normal sACE but a positive Kveim test.
Findings:
- All five patients presented with iris nodules.
- Two patients developed mutton fat keratic precipitates.
- One patient experienced peripheral retinal periphlebitis.
Implications:
- FHU may represent a secondary ocular manifestation of sarcoidosis.
- This suggests FHU might not be a primary idiopathic uveitis syndrome.
- Routine uveitis investigations are advised for patients with suspected sarcoidosis-related FHU.
