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Residual renal function and nutritional parameters in CAPD

R Scanziani1, B Dozio, G Bonforte

  • 1Renal Unit, Desio Hospital, Milan, Italy.

Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis
|January 1, 1995
PubMed
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Patients with residual renal function (RRF) on continuous ambulatory peritoneal dialysis (CAPD) show better nutritional status, including higher transferrin and albumin levels, compared to those without RRF, even with equal dialysis clearance. This highlights the importance of preserving kidney function in CAPD patients.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Nutritional Science

Background:

  • Residual renal function (RRF) is crucial for small molecule clearance in continuous ambulatory peritoneal dialysis (CAPD).
  • Nutritional status is a key determinant of outcomes in patients undergoing dialysis.

Purpose of the Study:

  • To investigate differences in nutritional parameters between CAPD patients with and without RRF.
  • To compare patients with equal total weekly clearance (KT/V) to isolate the effect of RRF on nutrition.

Main Methods:

  • Compared two groups of 7 CAPD patients each, matched for KT/V, age, dialysis duration, body weight, and BMI.
  • Group A had no RRF, while Group B had RRF contributing approximately 15% to KT/V.
  • Assessed nutritional markers including transferrin, normalized protein catabolic rate (PCRN), and albumin.

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Main Results:

  • Patients with RRF (Group B) exhibited significantly higher transferrin levels (278 vs. 209 mg/dL, p < 0.006).
  • Group B also showed a higher normalized protein catabolic rate (1.11 vs. 0.87 g/kg/day, p = 0.00).
  • Albumin levels were significantly higher in patients with RRF (3.55 vs. 3.31 mg/dL, p < 0.02).

Conclusions:

  • Residual renal function in CAPD patients is associated with improved nutritional status.
  • Preserving RRF may be beneficial for maintaining better protein and overall nutritional markers.
  • These findings underscore the clinical significance of RRF beyond just solute clearance in CAPD management.