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Intrathecal immune response in neonatal Flavobacterium meningosepticum meningitis
T G Abrahamsen1, T E Mollnes, B Vandvik
1Department of Pediatrics, Rikshospitalet, Oslo, Norway.
Biology of the Neonate
|January 1, 1995
Abstract:
Neonates are predisposed to serious infections such as meningitis, probably due to their immature host reaction to the pathogens. We have studied the intrathecal immune response in 2 newborns with Flavobacterium meningosepticum meningitis. They showed a significant elevation of immunoglobulin indices ( >1.10), also after the CSF had become sterile with a normalized cell count. In addition, an intrathecal increase and subsequent decrease of both C3dg and TCC (terminal complement complex) were observed in 1 patient. We conclude that immunoglobulin production and complement activation may occur in neonatal CSF.