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Related Experiment Videos

The clinical experience with antiangiogenic agents

J L Marshall1, M J Hawkins

  • 1Lombardi Cancer Center, Georgetown University Hospital, Washington DC 20007, USA.

Breast Cancer Research and Treatment
|January 1, 1995
PubMed
Summary

Antiangiogenic agents show promise for cancer treatment, but novel clinical trial designs are needed. This review examines current data and experience with pentosan polysulfate.

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Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Antiangiogenic agents are recognized for potential use in treating malignant processes.
  • A significant number of these agents are entering clinical research.
  • Their novel angiostatic mechanism presents unique challenges for clinical application.

Purpose of the Study:

  • To review existing clinical data on antiangiogenic agents.
  • To discuss the challenges and potential necessity for new clinical trial designs.
  • To present personal experience with pentosan polysulfate.

Main Methods:

  • Review of published clinical trial data on antiangiogenic agents.
  • Analysis of clinical research challenges posed by these agents.
  • Inclusion of investigator's own experience with pentosan polysulfate.

Main Results:

  • Several antiangiogenic agents are currently in or have completed clinical trials.
  • The review synthesizes available clinical data from various sources.
  • Personal experience with pentosan polysulfate is incorporated.

Conclusions:

  • Antiangiogenic agents require careful consideration regarding clinical trial design.
  • Further research and data are necessary to optimize their use in cancer therapy.
  • Pentosan polysulfate represents one agent within this evolving therapeutic class.

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