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The CHILD nevus: a distinct skin disorder
Dermatology (Basel, Switzerland)
|January 1, 1995
Summary
The CHILD nevus is a distinct X-linked dominant skin disorder, previously misdiagnosed. Recognizing this condition is crucial for accurate diagnosis and genetic counseling, differentiating it from inflammatory linear verrucous epidermal nevus (ILVEN).
Area of Science:
- Dermatology
- Clinical Genetics
- Pathology
Background:
- The CHILD syndrome presents as a unilateral ichthyosiform and inflammatory nevus.
- This condition has been inaccurately described using various terms like epidermal nevus and ILVEN.
- Lack of a specific name has led to diagnostic confusion.
Purpose of the Study:
- To propose a distinct name for this nevus to aid clinical recognition.
- To delineate the diagnostic criteria for this specific skin disorder.
- To differentiate it from other epidermal nevi and conditions like ILVEN.
Main Methods:
- Clinical, histopathological, and ultrastructural features of the nevus were described.
- A comparative analysis with other epidermal nevi was conducted.
- Genetic inheritance patterns were investigated.
Main Results:
- The term CHILD nevus is proposed, characterized by ptychotropism, waxy scaling, and lateralization.
- Distinctive features include foamy histiocytes in papillae ('verruciform xanthoma').
- It is an inherited X-linked dominant, male-lethal trait, distinguishing it from other epidermal nevi.
Conclusions:
- The CHILD nevus is identified as a separate cutaneous entity.
- It should not be confused with ILVEN, especially when presenting as an isolated skin disorder.
- Identification is vital for genetic counseling due to risks for offspring.