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Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains
C J Lord1, S K Bohlander, E A Hopes
1Nuffield Department of Surgery, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK.
Abstract:
Development of novel congenic mouse strains has allowed us to better define the location of the diabetogenic locus, Idd3, on Chromosome (Chr) 3. Congenic strains were identified by use of published and newly developed microsatellite markers, their genomes fingerprinted by a rapid, fluorescence-based approach, and their susceptibility to type 1 diabetes evaluated. The maximum interval containing Idd3 is now approximately 4 cM.