Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferon-gamma in multiple myeloma

A Palumbo1, B Bruno, M Boccadoro

  • 1Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Ospedale Molinette, Italy.

Leukemia & Lymphoma
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feasibility Trial Protocol for a Remote Intentional Music Listening Intervention to Support Mental Health in Individuals with Chronic Stroke.

medRxiv : the preprint server for health sciences·2025
Same author

Erratum to 'Reply to: Drug-drug interactions between palbociclib and proton pump inhibitors may significantly affect clinical outcome of metastatic breast cancer patients': [ESMO Open Volume 7, Issue 1, February 2022, 100393].

ESMO open·2022
Same author

Reply to: Drug-drug interactions between palbociclib and proton pump inhibitors may significantly affect clinical outcome of metastatic breast cancer patients.

ESMO open·2022
Same author

A retrospective evaluation of the indications, complications, and outcomes associated with epicardial pacemakers in 20 cats from a single institution.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2021
Same author

Quantitative analysis of movements in facial nerve palsy with surface electromyography and kinematic analysis.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2020
Same author

Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19.

Journal of endocrinological investigation·2020
Same journal

CPX‑351 vs. FLAG‑ida in patients with high-risk AML/MDS and MDS-related gene mutations: a subgroup analysis of the UK NCRI AML19 trial.

Leukemia & lymphoma·2026
Same journal

Specialist palliative care access and end-of-life hospitalizations in acute leukemia: a nationwide register study.

Leukemia & lymphoma·2026
Same journal

D-VRD vs. D-KRD induction in transplant-eligible multiple myeloma: a real-world comparison.

Leukemia & lymphoma·2026
Same journal

T-box factor EOMES is part of an aberrant network in Hodgkin lymphoma.

Leukemia & lymphoma·2026
Same journal

Overall survival of patients with chronic lymphocytic leukemia treated with venetoclax-obinutuzumab compared to age- and sex-matched general population.

Leukemia & lymphoma·2026
Same journal

Hypertension and time to treatment failure with acalabrutinib and ibrutinib in treatment-naïve CLL/SLL.

Leukemia & lymphoma·2026
See all related articles

Interferon-gamma (IFN-gamma) effectively inhibits multiple myeloma cell proliferation by targeting the key growth factor, Interleukin-6 (IL-6). This finding supports further in vivo studies for potential new cancer therapies.

Area of Science:

  • Oncology
  • Immunology
  • Hematology

Background:

  • Multiple myeloma exhibits biological heterogeneity, influenced by a complex cytokine network.
  • Cytokines play a crucial role in regulating plasma cell growth and tumor progression in multiple myeloma.
  • Interleukin-6 (IL-6) is recognized as a central growth factor for myeloma cells.

Purpose of the Study:

  • To investigate the antiproliferative effects of Interferon-gamma (IFN-gamma) on multiple myeloma cells.
  • To explore the mechanism of IFN-gamma's action, particularly its impact on IL-6 signaling.
  • To compare the efficacy of IFN-gamma with other agents like Interferon-alpha (IFN-alpha) and dexamethasone (DEX).

Main Methods:

  • In vitro proliferation assays using IL-6 dependent and independent myeloma cell lines.

Related Experiment Videos

  • Assessment of IFN-gamma's effect on fresh explanted bone marrow myeloma cells.
  • Evaluation of immunoglobulin (Ig) secretion and potential differentiating activity.

    • Main Results:

    • IFN-gamma demonstrated potent inhibition of myeloma cell proliferation, comparable to dexamethasone (DEX).
    • The antiproliferative effect of IFN-gamma was primarily attributed to the inhibition of IL-6.
    • IFN-alpha inhibited Ig secretion, while combined interferons (IFNs) affected both proliferation and Ig synthesis, mirroring DEX effects.
    • IFN-gamma also showed potential differentiating activity, augmenting monoclonal immunoglobulin secretion in some cases.

    Conclusions:

    • IFN-gamma exhibits significant in vitro antitumor activity against multiple myeloma cells.
    • The inhibition of IL-6 is a key mechanism underlying IFN-gamma's antiproliferative effects.
    • These findings provide a strong rationale for evaluating the in vivo therapeutic potential of IFN-gamma in multiple myeloma.