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Tetrasomy of chromosome 8 in a patient with acute myeloid leukemia
G M Cull1, D J Howe, M Stack-Dunne
1Department of Haematological Medicine, Taunton and Somerset Hospital, UK.
Leukemia & Lymphoma
|October 1, 1995
Abstract:
We report a case of acute myeloid leukaemia (AML), FAB classification M2, associated with tetrasomy 8. This chromosomal aberration was detected using conventional cytogenetics and flourescent in-situ hybridization (FISH). Using FISH, the pre-treatment cells with tetrasomy 8 were disomic for chromosome 7. A small number of tetrasomy 8 cells were found post-treatment, but these were tetrasomic for chromosome 7. The significance of this is considered, and the literature regarding tetrasomy 8 in acute myeloid leukaemia is reviewed.