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Arylnaphthalene lignans as novel series of hypolipidemic agents raising high-density lipoprotein level
T Iwasaki1, K Kondo, T Nishitani
1Research Laboratories of Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Chemical & Pharmaceutical Bulletin
|October 1, 1995
Abstract:
A series of arylnaphthalene lignans were synthesized and tested for hypolipidemic activity. The most potent compound (4b) (TA-7552) not only reduced serum cholesterol, but also increased high-density lipoproteins cholesterol in rats. The effective dose of 4b is 100 times less than that of cholestyramine. Structure-activity relationships are discussed.