Synergists for retinoid in cellular differentiation of human promyelocytic leukemia cells HL-60
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H Umemiya1, E Kawachi, H Kagechika
1Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|October 1, 1995
Abstract:
4-[5H-2,3-(2,5-Dimethyl-2,5-hexano)-5-methyldibenzo[b, e]diazepin-11-yl]benzoic acid (4) enhanced the differentiation-inducing activity of retinoic acid (1) and of a synthetic retinoid Am80 (2) toward human promyelocytic leukemia cells HL-60, although 4 alone did not induce differentiation. The synergistic effect of 4 on the activities of retinoids was also seen in suppression of proliferation of HL-60 cells.