Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid function parameters during a selenium repletion/depletion study in phenylketonuric subjects

M R Calomme1, J B Vanderpas, B François

  • 1School of Medicine and Pharmaceutical Sciences, Antwerp-Wilrijk, Belgium.

Experientia
|December 18, 1995
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preconditioning in hypoxic-ischemic neonate mice triggers Na<sup>+</sup>-Ca<sup>2+</sup> exchanger-dependent neurogenesis.

Cell death discovery·2022
Same author

Measurement of the Inclusive and Differential Higgs Boson Production Cross Sections in the Decay Mode to a Pair of τ Leptons in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2022
Same author

Search for long-lived particles decaying to leptons with large impact parameter in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2022
Same author

Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2022
Same author

Search for Long-Lived Particles Decaying in the CMS End Cap Muon Detectors in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2022
Same author

Measurements of the Electroweak Diboson Production Cross Sections in Proton-Proton Collisions at sqrt[s]=5.02  TeV Using Leptonic Decays.

Physical review letters·2021

Selenium supplementation normalized selenium levels and glutathione peroxidase activity in children with phenylketonuria (PKU). This intervention also influenced thyroid function parameters, suggesting a role for selenium in thyroid hormone metabolism.

Area of Science:

  • Nutritional Biochemistry
  • Endocrinology
  • Pediatric Metabolism

Background:

  • Phenylketonuria (PKU) patients often have restricted diets, leading to limited selenium (Se) intake.
  • Low selenium levels can impact various physiological processes, including thyroid function.
  • Glutathione peroxidase (GSH-Px) activity is a key indicator of selenium status.

Purpose of the Study:

  • To investigate the effects of selenium repletion on thyroid function in children with PKU.
  • To assess the impact of selenium supplementation on plasma selenium concentrations and GSH-Px activity in PKU subjects.

Main Methods:

  • A selenium repletion/depletion study was conducted in PKU children.
  • Dosage: 1 microgram Se/kg/day.
  • Measurements included plasma selenium, GSH-Px activity, and thyroid function parameters (T4, FT4, rT3).

Related Experiment Videos

Main Results:

  • Selenium supplementation normalized plasma Se concentrations and GSH-Px activity in PKU children.
  • Thyroid hormones (T4, FT4, rT3) initially decreased during Se supplementation but remained within physiological ranges.
  • Thyroid hormone levels returned to baseline after selenium supplementation ceased.

Conclusions:

  • Selenium supplementation effectively corrects selenium deficiency in PKU subjects.
  • Selenium influences thyroid hormone metabolism in PKU patients, likely through increased type I 5'-deiodinase activity.
  • These findings highlight the importance of monitoring and potentially supplementing selenium in PKU management.