Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p53 expression in ulcerative colitis: a longitudinal study

M Ilyas1, I C Talbot

  • 1Colorectal Cancer Unit, Imperial Cancer Research Fund, St Mark's Hospital, Northwick Park, Harrow, Middlesex.

Gut
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pf41 serological profiling reveals potential malaria exposure in low transmission setting in the Menoreh Hills, Central Java, Indonesia.

BMC microbiology·2026
Same author

Serological evidence of continued exposure to <i>Plasmodium falciparum</i> among residents in a near-elimination setting.

Frontiers in microbiology·2026
Same author

Work-Related Fatigue Among Indonesian Offshore Oil and Gas Workers.

Occupational medicine (Oxford, England)·2024
Same author

Vulnerable newborn types: analysis of subnational, population-based birth cohorts for 541 285 live births in 23 countries, 2000-2021.

BJOG : an international journal of obstetrics and gynaecology·2023
Same author

Drought stress enhances the efficiency of floral dip method of Agrobacterium-mediated transformation in Arabidopsis thaliana.

Brazilian journal of biology = Revista brasleira de biologia·2022
Same author

Analysis of Germin-like protein genes family in Vitis vinifera (VvGLPs) using various in silico approaches.

Brazilian journal of biology = Revista brasleira de biologia·2022
Same journal

USP20 promotes CD8<sup>+</sup> T cell exhaustion and impairs KRAS<sup>G12D</sup> inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer.

Gut·2026
Same journal

CTCF-rs705704-SUOX axis is important for the association between hypothyroidism and metabolic dysfunction-associated steatotic liver disease.

Gut·2026
Same journal

<i>Helicobacter pylori</i> infection, treatment and colorectal cancer risk by genetic predisposition: evidence from two randomised trials.

Gut·2026
Same journal

Correction: Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.

Gut·2026
Same journal

Correction: Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases.

Gut·2026
Same journal

Cancer risk in autoimmune gastritis: perspectives from a Chinese cohort.

Gut·2026
See all related articles

p53 mutations are typically a late occurrence in ulcerative colitis-associated colorectal carcinoma (UCACRC) development. This study found p53 overexpression usually appears close to the time of cancer diagnosis, not years prior.

Area of Science:

  • Oncology
  • Gastroenterology
  • Molecular Biology

Background:

  • Sporadic colorectal carcinoma (CRC) development involves p53 mutations as a late event.
  • The timing of p53 mutations in ulcerative colitis-associated colorectal carcinoma (UCACRC) is uncertain, with some studies suggesting it may be an early event.

Purpose of the Study:

  • To determine the temporal occurrence of p53 mutations during neoplasia development in ulcerative colitis.
  • To investigate whether p53 mutations are an early or late event in UCACRC.

Main Methods:

  • Immunohistochemistry using the DO-7 monoclonal antibody was performed on colorectal resection specimens and prior biopsy specimens from 10 patients with ulcerative colitis.
  • p53 protein expression was assessed in neoplastic tissues from patients with a history of dysplasia.

Related Experiment Videos

Main Results:

  • Seven out of 10 resection specimens showed p53 overexpression.
  • p53 overexpression was detected in only two cases two years prior to carcinoma or high-grade dysplasia diagnosis.
  • Five cases were negative for p53 overexpression between one and four years before resection.

Conclusions:

  • p53 overexpression is generally a late event in the progression of UCACRC.
  • These findings suggest that p53 mutations do not typically precede the development of high-grade dysplasia or carcinoma in UCACRC.