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Related Experiment Videos

Cardiomyopathy: a role for nitric oxide?

A de Belder1, S Moncada

  • 1Department of Cardiology, King's College Hospital, London, UK.

International Journal of Cardiology
|July 1, 1995
PubMed
Summary

Inflammatory heart disorders may involve increased nitric oxide (NO) production. Targeting this pathway could offer new therapeutic strategies for conditions like cardiomyopathy.

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Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Inflammatory heart disorders are characterized by negative inotropism, myocardial dilatation, and cytotoxicity.
  • Increased generation of nitric oxide (NO) is a potential mechanism underlying these cardiac dysfunctions.

Purpose of the Study:

  • To review the hypothesis linking immunological induction of a high output NO pathway to inflammatory heart disorders.
  • To evaluate existing data supporting the presence of this pathway in animal and human cardiomyopathies.

Main Methods:

  • Literature review of experimental studies.
  • Analysis of data from animal models and human patients with cardiomyopathic disorders.

Main Results:

  • Evidence suggests that a high output NO pathway, induced immunologically, may contribute to cardiac dysfunction in inflammatory conditions.
  • This pathway has been observed in both experimental animal models and human cardiomyopathies.

Conclusions:

  • The high output NO pathway is a plausible contributor to the pathophysiology of inflammatory heart disorders.
  • Modulating this NO pathway presents a potential therapeutic target for patients suffering from these conditions.

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