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Plasminogen activators, venous leg ulcers and reepithelialization
International Journal of Dermatology
|October 1, 1995
Summary
This study found higher levels of urokinase (UPA) at the edges and floor of chronic venous hypertension leg ulcers. This suggests UPA may promote wound healing by attracting cells like keratinocytes.
Area of Science:
- Biochemistry
- Dermatology
- Wound Healing Research
Background:
- Chronic venous hypertension (CVH) causes leg ulcers linked to reduced fibrinolysis and tissue anoxia.
- Perivenular fibrin-film formation is a key factor in CVH leg ulcer pathogenesis.
Purpose of the Study:
- To spectrophotometrically evaluate urokinase (UPA) levels in leg ulcers associated with CVH.
- To compare UPA distribution in ulcer edges, floors, and surrounding skin.
Main Methods:
- Biopsies were taken from ulcer edges, floors, and perilesional skin of 10 CVH patients.
- UPA activity was measured spectrophotometrically at 405 nm.
- UPA levels were compared to 10 healthy control subjects.
Main Results:
- UPA was detected in all examined areas, including controls.
- Significantly higher UPA levels were observed at the ulcer edge compared to the center and perilesional skin.
- UPA levels in the ulcer floor were also notable.
Conclusions:
- Elevated UPA at ulcer edges and floors suggests a chemoattractant role for keratinocytes, potentially aiding reepithelialization.
- UPA may also contribute to wound healing through neoangiogenesis and fibroblast chemoattraction.