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Ampicillin plus ciprofloxacin therapy of experimental endocarditis caused by multidrug-resistant Enterococcus faecium
D Landman1, J M Quale, N Mobarakai
1Department of Medicine (111E), Department of Veterans Affairs Medical Center, Brooklyn, New York 11209, USA.
The Journal of Antimicrobial Chemotherapy
|July 1, 1995
Abstract:
The combination of ampicillin and ciprofloxacin displayed bactericidal in-vitro activity against two strains of Enterococcus faecium which were highly resistant to ampicillin, vancomycin, and aminoglycosides. This antibiotic combination was used to treat rabbits with experimental endocarditis caused by these strains. Although a significant decrease in vegetation bacterial counts occurred with one strain, the degree of killing did not approach that of penicillin with an aminoglycoside against susceptible enterococci.