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Block copolypeptides. 1. Synthesis and solid state conformational studies

T Hayashi, A G Walton, J M Anderson

|March 1, 1977

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High molecular weight triblock copolypeptides were synthesized and characterized. These novel materials exhibit distinct secondary structures, with gamma-benzyl L-glutamate and L-leucine blocks forming alpha-helices and L-valine blocks forming beta-sheets.

Area of Science:

Polymer Chemistry
Materials Science
Biomaterials

Background:

Triblock copolypeptides offer unique properties due to their defined block structures.
Understanding the solid-state conformation is crucial for developing new materials.

Purpose of the Study:

To synthesize and characterize high molecular weight triblock copolypeptides of gamma-benzyl L-glutamate (G) and L-leucine or L-valine.
To investigate the solution and solid-state conformations of these novel copolypeptides.
To compare their properties with random copolymers and homopolypeptides.

Main Methods:

Synthesis of triblock copolypeptides.
Solubility and solution conformation analysis.
Solid-state characterization using infrared spectroscopy and polarized infrared measurements.

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Main Results:

Triblock copolypeptides of gamma-benzyl L-glutamate (G) and L-leucine/L-valine were successfully prepared.
Infrared and solid-state analyses revealed distinct secondary structures: alpha-helical for G and L-leucine blocks, beta-sheet for L-valine blocks.
Polarized infrared measurements indicated chain alignment parallel to the orientation direction in films.

Conclusions:

The synthesized triblock copolypeptides form well-defined secondary structures in the solid state.
These findings establish a foundation for exploring the tertiary structure and mechanical properties of these materials.