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Acid-base changes after severe birth acidaemia

A G Farkas1, S C Robson, A Kyei-Mensah

  • 1Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, University of London, Queen Charlotte's and Chelsea Hospital, U.K.

Journal of Perinatal Medicine
|January 1, 1995
PubMed
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Severe birth acidaemia in newborns showed significant acid-base recovery within one hour. Full pH normalization was observed by four hours, indicating a robust physiological response in neonates.

Area of Science:

  • Neonatal physiology
  • Perinatal medicine
  • Acid-base balance

Background:

  • Severe birth acidaemia is a critical condition in newborns.
  • Understanding the recovery trajectory of acid-base balance is crucial for neonatal care.

Purpose of the Study:

  • To prospectively evaluate acid-base changes following severe birth acidaemia.
  • To determine the timeline for pH recovery in affected neonates.

Main Methods:

  • Prospective identification of 45 term infants with severe birth acidaemia (pH ≤ 7.05).
  • Monitoring of umbilical artery pH, base deficit, and pCO2.
  • Assessment of acid-base status at one hour of age and follow-up pH measurements.

Main Results:

Related Experiment Videos

  • At one hour, median pH improved to 7.29, correlating with pCO2 levels.
  • Neonates with pH ≤ 7.25 at one hour showed complete recovery by four hours.
  • One death and three cases of encephalopathy were noted among NICU admissions, with neurological recovery by follow-up.

    • Conclusions:

    • Acid-base balance shows significant recovery within one hour after severe birth acidaemia.
    • Complete pH normalization is typically achieved by four hours of age.
    • While severe acidaemia poses risks, neonatal outcomes can be favorable with timely recovery.