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Related Experiment Videos

[Familial malignant melanoma]

T Takenouchi1, M Ito

  • 1Department of Dermatology, Niigata University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

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Familial malignant melanoma (FMM) is rare in Japan, with earlier onset than sporadic cases. Genetic studies suggest autosomal dominant inheritance and loci on chromosomes 1p36 and 9p21.

Area of Science:

  • Dermatology
  • Genetics
  • Oncology

Context:

  • Familial malignant melanoma (FMM) is estimated at 8-12% globally, but is rare in Japan.
  • Only eleven Japanese FMM cases, including three from one family, have been reported.
  • FMM often presents with a dysplastic nevus syndrome phenotype.

Purpose:

  • To summarize the characteristics and genetic basis of familial malignant melanoma (FMM) in Japan.
  • To compare FMM onset age with sporadic malignant melanoma.
  • To review the genetic inheritance patterns and loci associated with FMM.

Summary:

  • Mean age at FMM onset is younger than sporadic melanoma, though early detection may influence this.
  • The inheritance pattern is presumed autosomal dominant with incomplete penetrance.

Related Experiment Videos

  • Linkage studies identify at least two FMM loci on chromosome 1p36 and 9p21, indicating genetic heterogeneity.

    • Impact:

    • Highlights the rarity and distinct features of FMM in the Japanese population.
    • Supports the genetic heterogeneity of FMM.
    • Provides insights into the genetic predisposition for melanoma.