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Behavioral effects of MK-801 in morphine-dependent and non-dependent mice
I Belozertseva1, E Zvartau, A Bespalov
1Department of Pharmacology, Pavlov Medical University, St.-Petersburg, Russia.
Abstract:
The behavioral effects of MK-801 were compared in morphine-dependent and non-dependent mice. The dose of MK-801 selected for these studies was previously demonstrated to attenuate some of the morphine withdrawal signs. Subjects were repeatedly exposed to morphine (8 days, b.i.d., 10-100 mg/kg, s.c.). Twenty-four hours after last morphine injection mice received naloxone (0.1 mg/kg, s.c.) and the observation was commenced. Animals were pretreated with either MK-801 (0.1 mg/kg, i.p.) or saline 30 min prior to testing. It was found that the behavioral effects of MK-801 (decreased sociability, and increased rate of transitions between behavioral elements, locomotion, grooming) were less pronounced in morphine-dependent compared to non-dependent subjects. However, the intensified almost stereotypic eating possibly reflected increased psychotomimetic potency of MK-801 in morphine-withdrawn animals.
Insights
MK-801
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Morphine dependence is a significant clinical issue.
- Understanding the interaction between NMDA receptor antagonists and opioid withdrawal is crucial.
Purpose of the Study:
- To investigate the behavioral effects of MK-801 in morphine-dependent and non-dependent mice.
- To assess if MK-801's effects differ based on morphine dependence status.
Main Methods:
- Mice were rendered morphine-dependent through repeated injections.
- Behavioral assessments were conducted after naloxone-induced withdrawal.
- Animals were pretreated with MK-801 or saline before testing.
Main Results:
- The behavioral effects of MK-801, such as reduced sociability and altered activity, were less pronounced in morphine-dependent mice.
- Morphine-withdrawn animals exhibited intensified eating, suggesting increased psychotomimetic effects of MK-801.
Conclusions:
- Morphine dependence alters the behavioral response to MK-801.
- MK-801 may have differential psychotomimetic effects in opioid-withdrawn states.